ABSTRACT
ABSTRACT Cicatricial ectropion may be a consequence of certain systemic diseases as well as the result of drug use. Our goal here was to research the different causes of this condition as reported in the literature, including more recently suspected etiologies. A detailed PubMed literature search indicated many different etiologies were associated with cicatricial ectropion development, from severe cases of systemic diseases, such as ichthyosis and lupus erythematosus, to reversible scenarios secondary to anti-glaucomatous drug use. More recently reported connections include periorbital necrotizing fasciitis, frontal osteomyelitis, and antineoplastic agents. Indeed, cicatricial ectropion may be highly symptomatic; being able to determine its real etiology is imperative to managing patients properly. In this investigation, we felt that an explicitly multidisciplinary approach was essential, especially for cases associated with systemic conditions.
RESUMO O ectrópio cicatricial pode ser uma consequência de certas doenças sistêmicas, bem como o resultado do uso de drogas. Nosso objetivo aqui foi pesquisar as diferentes causas desta condição, conforme relatado na literatura, incluindo mais recentemente suspeitas de etiologias. Uma pesquisa bibliográfica detalhada do PubMed indicou que muitas etiologias diferentes estavam associadas ao desenvolvimento do ectrópio cicatricial, desde casos graves de doenças sistêmicas, como ictiose e lúpus eritematoso, até cenários reversíveis secundários ao uso de drogas antiglaucomatosas. Conexões relatadas mais recentemente incluem fasceíte necrosante periorbitária, osteomielite frontal e agentes antineoplásicos. De fato, o ectrópio cicatricial pode ser altamente sintomático; ser capaz de determinar sua etiologia real é imperativo para o manejo adequado dos pacientes. Nesta investigação, sentimos que uma abordagem explicitamente multidisciplinar era essencial, especialmente para casos associados a doenças sistêmicas.
Subject(s)
Humans , Cicatrix/etiology , Cicatrix/pathology , Ectropion/etiology , Ectropion/pathology , Lupus Erythematosus, Cutaneous/complications , Arthritis, Psoriatic/complications , Eyelids/pathology , Ichthyosis/complicationsABSTRACT
El lupus eritematoso neonatal (LEN) es una enfermedad poco frecuente del recién nacido debida al paso transplacentario de anticuerpos maternos anti RO/SSA, anti LA/SSB y/o anti U1RNP, en la cuál las afectaciones cutáneas y cardíacas son las más destacadas. Presentamos un caso de una niña con manifestaciones dermatológicas y cardíacas tratadas en el Hospital General de Niños Pedro de Elizalde, hija de madre asintomática.
Subject(s)
Humans , Female , Infant, Newborn , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Autoantibodies , Heart Block/etiology , Lupus Erythematosus, Cutaneous/complications , Lupus Erythematosus, Systemic/complicationsABSTRACT
Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatobiliary disease. During the past decade, however, it has become clear that central nervous disease may also be a manifestation of neonatal lupus. We report a male neonate with the disease who had focal seizures in addition to cutaneous lupus, anemia, and thrombocytopenia. Brain ultrasound revealed normal ventricular size without a midline shift or intracranial or intraventricular hemorrhage. A brain CT showed generalized low density involving the periventricular and deep white matter. A sleep EEG revealed rare spikes axial to the right parietal lobe. The neonate had a high titer of antinuclear antibodies (1:640) with a speckled pattern, anti-Ro/SSA and anti-La/SSB antibodies, but no anti-dsDNA antibodies. He was given anti-convulsant drugs with dramatic improvement of his symptoms. One month later, a sleep EEG was normal, and he had no further seizures.
Subject(s)
Anemia , Anticonvulsants/therapeutic use , Autoantigens/immunology , Humans , Infant, Newborn , Lupus Erythematosus, Cutaneous/complications , Lupus Erythematosus, Systemic/complications , Male , Phenytoin/therapeutic use , Ribonucleoproteins/immunology , Seizures/etiology , ThrombocytopeniaABSTRACT
We describe case report of a 45 days old male baby with neonatal lupus erythematosus, who presented with 3rd degree congenital heart block and depigmented skin lesions on face and upper part of body. Diagnosis of the baby was confirmed by anti nuclear levels and skin biopsy.
Subject(s)
Antibodies, Antinuclear/analysis , Heart Block/congenital , Humans , Infant , Lupus Erythematosus, Cutaneous/complications , Male , Skin Pigmentation/immunologyABSTRACT
Exantema es una erupción de la piel con lesiones de distinto tipo, configuración y disposición. El diagnóstico diferencial para pacientes febriles con exantema es extenso. Las posibles causas son enfermedades infecciosas, drogas, enfermedades dermatológicas, inmunológicas y/o neoplásicas. Una historia detallada y un examen físico cuidadoso pueden ser esenciales para hacer un diagnóstico correcto. La historia debe incluir el sitio de comienzo, porcentaje y dirección de extensión, presencia o ausencia de prurito y relación temporal con la fiebre. En este artículo se revisarán diagnósticos no infecciosos de exantemas febriles
Subject(s)
Humans , Exanthema , Fever , Arthritis, Juvenile , Dermatitis, Allergic Contact/complications , Dermatitis, Exfoliative , Dermatomyositis , Exanthema , Graft vs Host Disease , Hypersensitivity , Lupus Erythematosus, Cutaneous/complications , Psoriasis , Serum Sickness , Sezary Syndrome/complications , Stevens-Johnson Syndrome/complications , Stevens-Johnson Syndrome/chemically induced , Sweet Syndrome/complications , Hypereosinophilic Syndrome/complications , Mucocutaneous Lymph Node Syndrome/complications , Still's Disease, Adult-Onset , Sunburn , VasculitisABSTRACT
Calcificação de tecidos moles tem sido frequentemente descrita em associação com esclerose sistêmica progressiva, síndrome CREST e dermatomiosite, porém raramente associado com o lúpus eritematoso sistêmico. Embora a etiopatogenia da calcinose associada a essas doenças não esteja esclarecida, várias hipóteses têm sido propostas, baseadas em alterações teciduais em locais de trauma ou inflamação crônica. Descreve-se o caso de uma paciente com lúpus cutâneo evoluindo com calcificação difusa de tecidos moles. A presença de calcinose universalis em lúpus cutâneo é muito rara e também de etiopatogenia não definida, não se afastando a possibilidade de ser apenas uma coincidência de doenças
Subject(s)
Humans , Female , Aged , Calcinosis , Lupus Erythematosus, Cutaneous/complicationsABSTRACT
El lupus Eritematoso es una enfermedad inflamatoria, heterogenéa, que puede presentarse en pacientes en edad pediátrica. Se realiza el presente estudio retrospectivo de los casos pediátricos con diagnóstico de lupus eritematoso, que fueron evaluados y controlados en la consulta de dermatología pediátrica del Hospital Universitario en septiembre 1989 y septiembre 1994, haciendo énfasis en la presencia de manifestaciones cutáneas. Se comparan los resultados con la literatura nacional e internacional
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Adolescent , Child , Lupus Erythematosus, Cutaneous/complications , Lupus Erythematosus, Cutaneous/diagnosisSubject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Alopecia Areata/drug therapy , Alopecia Areata/therapy , Alopecia/diagnosis , Anthralin/therapeutic use , Minoxidil/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Allergens/therapeutic use , Alopecia/drug therapy , Cyclosporine/therapeutic use , Inosine/therapeutic use , Lichen Planus/complications , Lupus Erythematosus, Cutaneous/complications , Practice Guidelines as Topic , Scalp/drug effects , Trichotillomania/therapyABSTRACT
We present a case of chronic cutaneous lupus erythematosus (CCLE) in a patient who subsequently became infected with human immunodeficiency virus, HIV-1. The symptoms attributed to CCLE had persisted for years, and curiously had disappeared by the time the patient probably became infected with HIV-1. Even if there is lack of evidence to consider HIV-1 infection as direct causative agent in the clinical remission of CCLE, this response is in accordance with previous reports from other authors, regarding the attenuating role of HIV on the clinical course of the systemic lupus erythematosus. Even if the number of reported cases is very low it is of the upmost importance to establish whether this hypothesis is correct or not, since both diseases present great difficulties regarding diagnosis, due to the important overlapping between symptoms and serological tests.